Selected Publications


1.     Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression.

Lin JD, Nishi H, Poles J, Niu X, Mccauley C, Rahman K, Brown EJ, Yeung ST, Vozhilla N, Weinstock A, Ramsey, S Fisher EA and Loke P. JCI insight, Volume 4, Issue 4, February, 2019.

PMID: 30830865

2.     Ly6C(high) monocytes become alternatively activated macrophages in schistosome granulomas with help from CD4+ cells.
Girgis NM, Gundra UM, Ward LN, Cabrera M, Frevert U, Loke P.
PLoS Pathog. 2014 Jun 26;10(6):e1004080. doi: 10.1371/journal.ppat.1004080. eCollection 2014 Jun.
PMID: 24967715

3.     Helminth colonization is associated with increased diversity of the gut microbiota.
Lee SC, Tang MS, Lim YA, Choy SH, Kurtz ZD, Cox LM, Gundra UM, Cho I, Bonneau R, Blaser MJ, Chua KH, Loke P.
PLoS Negl Trop Dis. 2014 May 22;8(5):e2880. doi: 10.1371/journal.pntd.0002880. eCollection 2014 May.
PMID: 24851867

4.     Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.
Gundra UM, Girgis NM, Ruckerl DA, Jenkins S, Ward LN, Kurtz ZD, Wiens KE, Basu-Roy U, Mansukhani A, Allen JE, Loke P.  
Blood (In Press).
PMID: 24695852

5.     Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences.
Cox LM, Yamanishi S, Sohn J, Alekseyenko AV, Leung JM, Cho I, Kim SG, Li H, Gao Z, Mahana D, Zárate Rodriguez JG, Rogers AB, Robine N, Loke P, Blaser MJ.
Cell. 2014 Aug 14;158(4):705-21. doi: 10.1016/j.cell.2014.05.052.
PMID: 25126780

6.     Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus.
Ramanan D, Tang MS, Bowcutt R, Loke P, Cadwell K.
Immunity. 2014 Aug 21;41(2):311-24. doi: 10.1016/j.immuni.2014.06.015. Epub 2014 Jul 31.
PMID: 25088769

7.     IL-22 producing CD4+ cells are depleted in actively inflamed colitis tissue.
Leung JM, Davenport M, Wolff MJ, Wiens KE, Abidi WM, Poles MA, Cho I, Ullman T, Mayer L, Loke P.
Mucosal Immunology 2013 May 22. doi: 10.1038/mi.2013.31.
PMID: 23695510

8.     Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.
Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P.
PLoS Pathogens. 2012 Nov;8(11):e1003000.
PMID: 23166490

9.     Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P.
PLoS Pathog. 2012;8(8):e1002883. doi: 10.1371/journal.ppat.1002883. Epub 2012 Aug 23.
PMID: 22927819

10.  Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.
Wei J, Loke P, Zang X, Allison JP. J
Exp Med. 2011 Aug 1;208(8):1683-94.
PMID: 21727190

11.  IL-22+ CD4+ T cells are associated with therapeutic Trichuris trichiura infection in an ulcerative colitis patient.
Broadhurst MJ, Leung JM, Kahsyap V, McCune JM, Mahadevan U, McKerrow JH, Loke P.
Science Translational Medicine 2010 Dec 1;2(60):60ra88.
PMID: 21123809

Full list: